Authors: Gülten TOPRAK, Ä°lhan SABANCILAR, Nida ÖZCAN, Hüseyin ALKAN
Objectives: Oxidative stress is thought to play a role in chronic liver diseases, but its effect on chronic hepatitis C (CHC) remains unclear. The aim of this study was to investigate oxidative stress parameters such as total oxidant and antioxidant capacity, ferritin and vitamin D levels among patients with CHC.
Materials and Methods: A total of 49 patients with CHC infection were included in the study. The control group (50 subjects) consisted of healthy blood donors. Total oxidant status (TOS), total antioxidant status (TAS), ferritin and vitamin D levels were measured in both groups. TAS and TOS levels were determined spectrophotometrically, ferritin and vitamin D levels and Hepatitis C virus antibodies (Anti-HCV) were determined by electrochemiluminescence method.
Results: The mean TOS value of CHC patients was found higher than control group( 74.44 ± 55.54 versus 42.73 ± 13.48). Mean ferritin and Vitamin D levels in CHC patients were found as 218.09 ± 27.47 and 23.72 ± 14.60 respectively. TOS and ferritin levels were significantly higher (p<0.05) and vitamin D levels were significantly lower (p <0.05) in CHC patients. There wasn’t any statistically significant difference in TAS levels between CHC patients and the control group(p>0.05).
Conclusion: High oxidative stress markers, TOS and ferritin, suggest that oxidative stress is increased in CHC. There is a need for extensive research involving more patients.
View/Download pdf