Authors: Gülten Toprak, Ilhan Sabancilar, Nida Özcan, Beran Yokus.
Background & Aim: Behçet's Disease (BD) is a chronic vascular-inflammatory multisystemic disease. Infectious, psychological, genetic and immunological factors are thought to play role in BD. Recent studies have shown that oxidative stress is associated with various diseases. In this study, some oxidative stress parameters were investigated in patients with BD to investigate the relationship of the disease with oxidative stress.
Materials & Methods: The study included 35 patients with BD who admitted to the dermatology clinic of Dicle University Hospital and 37 healthy individuals as the control group. Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Paraoxonase (PON-1), Ferritin, Folic Acid (folate) and D-vit levels were examined in the serum samples of both groups included in the study.
Results: Compared to the control group, serum TOS, ferritin and folate levels were significantly higher in patients with BD, while TAS and D-vit levels were significantly lower(p<0.05). PON-1 level was found lower in BD patients than the control group, but the difference was not statistically significant.
Conclusion: High oxidative stress and degraded antioxidant system parameters in patients with BD, may indicate the role of oxidative stress in the pathogenesis of the disease.