Stem Cell and Regenerative Medicine

Abstract

Osteoarthritis Treated with Telomerase-Positive Adult Stem Cells in Animals and Humans

Henry E. Young, Mark O. Speight

Osteoarthritis results from mechanical injury to an articular joint. This condition usually requires 20 to 50 years to manifest fully. The presenting symptoms include increasing articular pain, osteophyte formation, and decreasing mobility. Telomerase-positive adult stem cells have been identified in multiple species of animals, including humans. Telomerase-positive adult stem cells act to restore damaged or missing cells and tissues by repair and/or regeneration. It was hypothesized that telomerase-positive adult stem cells would decrease pain and restore function in osteoarthritic animals, including humans. A German Shephard, Komodo dragon, Wedel crane, spectacled bear, and six humans (n=10) were treated with autologous telomerase-positive adult stem cells for osteoarthritic joints. Utilizing the standard protocol of in situ proliferation, in situ mobilization into the blood stream, harvest by venipuncture, isolation, segregation, and activation, telomerase-positive stem cells were resuspended in a local anesthetic and injected into the osteoarthritic joints of these subjects. By one-month after injection, all subjects demonstrated less pain and greater mobility.

View pdf