Authors: Mohammed M. Alkhashab, Dhafar M. Abdalfattah, Rawaa Y. Al-Rawee
Aim: Estimation of influence of metronidazole gel foam on Salivary Tumor Necrosis Factor and Interleukin-6 during lower third molar extraction by comparing the effect before and after extraction. In addition, evaluate the benefit of using metronidazole gel foam during the extraction of molar teeth.
Material and Methods: Twenty three patients were involved in this study, patients were classified into group I (control group) group II (metronidazole gel foam tested group ), saliva was taken from all patients by using salivate before extraction and seven days after extraction to measure the TNF-α and IL-6 by using (ELISA) kit.
Results: there is a significant decrease in the salivary interleukin-6 and TNF-α levels before extraction and after one week in both groups (p<0.05), negative correlation exist between salivary TNF-α and IL-6 in both groups, also there is no significant difference of the level of TNF-α between two groups (p=0.078), and a significant difference in the level of IL-6 (p=0.018) between two groups.
Conclusion: metronidazole gel foam produces a significant effect on salivary TNF-α and IL-6 when compared to its level in control and treatment group which may enhance healing of socket after extraction of lower third molar and decrease susceptibility of infection.
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