Gynecology & Reproductive Health

Open Access ISSN: 2639-9342


A Comparison of Vascular Endothelial Growth Factors (Vegf) Levels in Menstrual Blood Between Women with and Without Endometriosis

Authors: Andi Cakra, Nasrudin AM, Eddy Tiro, Sitti Maisuri T Chalid, Mardiah Tahir

Background: Vascular endothelial growth factor (VEGF) is one of the main stimuli in endometriosis angiogenesis. This study aims to compare VEGF levels in menstrual blood between women with and without endometriosis. This research was carried out in dr. Wahidin Sudirohusodo General Hospital and several hospitals in collaboration with the Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar.

Method: The method used was observational with a cross-sectional study design on 27 women with endometriosis and 17 women without endometriosis as a control group in February - July 2017. VEGF levels in menstrual blood were measured by the ELISA method.

Results & Discussion: Data were analysed using statistical analysis by chi-square test and Mann-Whitney test. The results showed that VEGF levels in women with endometriosis were significantly higher than those without endometriosis (22,080.93 ± 9,216.42 pg/ml vs. 8,526.65 ± 2,981.38 pg/ml, p<0.05).

Conclusion: We concluded that there was an increase in VEGF levels of menstrual blood in patients with endometriosis compared with those without endometriosis. These VEGF levels correlate positively with the stages of endometriosis. VEGF in menstrual blood can be used as biomarker and predictor examination panel to diagnose endometriosis which is minimally invasive.

View/Download pdf