Authors: Tarun Saxena, Manjari Saxena, Azeema Ozefa Ali.
Background: Development of type-2 diabetes remains ambiguous. There are some known risk factors like stress, lack of exercise etc. are described in diabetes. How risk factors affect insulin kinetics? Therefore to assess the risk factors and their possible effect on insulin kinetics in the study population was the main focus of the study.
Methods: This is a descriptive study done in retrospective manner in Ajmer central part of Rajasthan, India based on data collection of admitted patients. Data of 200 cases of diabetes (group A) was compared with 200 non-diabetic (group B) cases for dietary intake, history of stress and exercise. Blood samples were examined for lactic acid, PH, potassium levels.
Results: In group A and group B no major difference was there in BMI and positive family history. Group A cases had low carbohydrate intake in diet, severe mental exhaustion/stress and poor exercise schedule. This was associated with low lactic acid, alkaline PH and hypokalemia in group A.
Conclusion: Poor exercise and low carbohydrate diet are associated with low lactic acid resulting in alkaline PH associated with hypokalemia. Stress is associated with increase in basal sympathetic discharge resulting in hypokalemia. Low serum potassium possibly inhibits glucose and potassium entry into muscle at its receptor and simultaneously reduces insulin release. Chronicity of such conditions result in development of diabetes.
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