Authors: Aurelian Udristioiu, Manole Cojocaru, Liviu Martin, Gabriel Buciu, Alexandru Giubelan, Marius Stancu, Maria Daniela Papurica, Ioan-Ovidiu Gheorghe, Delia Nica-Badea, Gabriel Petre Gorecki.
In elderly people, cells can show DNA mutations and the accumulation of protein aggregates that impair physiological processes in the body. Several studies have shown that the activation of autophagy slows down the ageing process. The study groups included the materials, which published data on the relationship between restrictive diet and autophagy that prevent early ageing, chronic metabolic diseases and degenerative cells until cancer diseases.
Disturbances in the autophagy process can lead to chronic metabolic diseases, such as Parkinson's disease, type 2 diabetes, cancer and other diseases that occur with ageing. Reduction of Beclin 1 protein, a product of the ATG-7 gene, an autophagy promoter molecule, results in decreased levels of phagocytic receptors recycling and phagocytosis, example being Alzheimer's disease (AD), with the stored peptide β-amyloid (Aβ) inter--neuronal brain. A better regeneration of the body takes place during the black fast, in which senescent cells, (dead cells that no longer exercise any function, but instead produce inflammation in the body), are eliminated by autophagy and in their place the cells are stimulated by the stem cells of tissues from human body.
Aging and its associated conditions of illnesses, are due to genomic instability caused by DNA damage, telomere shortening, and epigenomic changes that modulate gene expression. Activation of autophagy delays the ageing process and maintains more time in a healthy human organism.
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