Authors: Pichaet Wiriyachitra, Preeya Leelahagul, Sirithip Wiriyachitra, Ramida Watanapokasin, Jannatthabhorn Janprasert, Sakda Sreesangkom.
Cancino®, a dietary supplement registered with the Thai FDA, was developed to prevent cancer, which has been increasing at an alarming rate, by building on the previous success of the formula of Mylife/Mylife100® in cancer treatment. The formulation is modified from that of Mylife/Mylife100® by using a different concentration of active ingredients from five edible plants, namely pennywort leaves, black sesame seeds, soybeans, guava fruit, and mangosteen aril. Consumers with low immunity who took 3 capsules of Cancino® per day before breakfast over a study period of 8 weeks experienced increased immunity as evidenced by the sharp increases in lymphocytes, CD4 and CD8 T cells. Most participants also demonstrated significant increases in their absolute mean telomere length simultaneously as they increased their immunity. In addition, they all exhibited autophagy induction, as indicated by the increase in the expression of Atg12 and LAMP1. All these results demonstrated that Cancino® is effective in cancer prevention, achieved through the combined effects of increased T cells, telomere elongation in previously existing and newly increased T cells, and autophagy induction.
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