Authors: Mahira Firudin kizi Amirova, Ellada Eldar qizi Huseynova, Ali Nadir oglu Aliyev, Fereh Ismail qizi Mammadova, Nigar Veliki kizi Melikova.
Background: The prevalence of cancer, including endometrial cancer, continues to grow. A prelude to cancer is thickening of the endometrium, one of the formidable signs of neoplasia development can be bleeding. In recent years, there have been reports in the literature on the possible role of vitamin D in the development of endometrial diseases, but the data in some cases have been quite contradictory. In this regard, we examined patients with endometrial hyperplasia who applied to the Oncology Center and Obstetrics and Gynecology Department of Azerbaijan Medical University in 2021- 2024 years.
The study aimed to investigate the relationship between vitamin D levels and the manifestations of hyperplasia and neoplasia, with the goal of developing a comprehensive set of corrective and preventive measures.
Methods: The patients were stratified into 3 groups: group I - patients with endometrium hyperplasia with bleeding diagnosed with neoplasia, group II - patients with endometrial hyperplasia and bleeding but without neoplasia, group III - patients with endometrial thickening but without bleeding and without oncology.
The hormonal panel was examined on the IMMULITE 2000 XPI (SIEMENS) analyzer. Test for 25-hydroxy vitamin D (25(OH)D) was conducted on ARCHITECT i1000 SR immunological analyzer (Abbott Park, IL). Study results were interpreted using the SPSS version 26.
Results: The most significant correlation in vitamin D levels and severity of disease manifestations was observed in the main group, namely endometrial hyperplasia associated with postmenopausal bleeding complicated by cancer.
Conclusion: We identified vitamin D deficiency as a risk factor among women with endometrial hyperplasia aggravated by neoplasia.
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